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Trombodipine

CAS No. 113658-85-8

Trombodipine( —— )

Catalog No. M33155 CAS No. 113658-85-8

Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Trombodipine
  • Note
    Research use only, not for human use.
  • Brief Description
    Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.
  • Description
    Trombodipine is an antithrombotic agent.
  • In Vitro
    Trombodipine is an antithrombotic agent. Exposure to 50 μM Trombodipine reveals an important stasis of growth. The percentage of inhibition exerted by 1 μM Trombodipine on day 3, 5 and 7 of the growth curve is 22.0±4.5, 32.0±3.0 and 29.4±6.0%, respectively (P<0.05). The inhibitory effect of Trombodipine on cell proliferation is reversible and after removal of Trombodipine the proliferation of the cells is resumed. Addition of Trombodipine reduces cell number in a dose-dependent manner over a period of 4 to?6 days in culture. When compare to control cultures at the latest time points investigated, 5 μM Trombodipine decreases the number of E19P cells and human VSMCs by 25 and 21%, respectively, whereas 50?μM Trombodipine reduces E19P and human VSMC number by 85 and 74%, respectively.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Antibiotic
  • Recptor
    Antibiotic
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    113658-85-8
  • Formula Weight
    448.49
  • Molecular Formula
    C21H24N2O7S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OCC)C1=C(NC(=C(C(=O)OCCN2C(=O)C=3C=CC=CC3S2(=O)=O)C1C)C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. del Rio M, et al. Antiproliferative effects of PCA-4230, a new antithrombotic drug, in vascular smooth muscle cells. Br J Pharmacol. 1997 Apr;120(7):1360-6.?
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