Tadalafil ( IC351, IC-351, IC 351, Tadalafil, Adcirca, Cialis )

Catalog No. M12614 CAS No. 171596-29-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Tadalafil
Note

Research use only, not for human use.
Brief Description

Tadalafil is a potent phosphodiesterase-5 (PDE5) inhibitor (IC50=1 nM).
Description

Tadalafil is a potent phosphodiesterase-5 (PDE5) inhibitor (IC50=1 nM); no inhibition on most of the other families of PDEs, with the exception of PDE11.Sexual Dysfunction Approved
Synonyms

IC351, IC-351, IC 351, Tadalafil, Adcirca, Cialis
Pathway

Angiogenesis
Target

PDE
Recptor

PDE5
Research Area

Endocrinology
Indication

Sexual Dysfunction

CAS Number

171596-29-5
Formula Weight

389.40
Molecular Formula

C22H19N3O4
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 52 mg/mL
SMILES

O=C([C@@]1([H])CC2=C([C@@H](C3=CC(OCO4)=C4C=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
Chemical Name

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-

1. Blount MA, et al. Mol Pharmacol, 2004, 66(1), 144-152.
2. Ring BJ, et al. Clin Pharmacol Ther, 2005, 77(1), 63-75.

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