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TP455

CAS No. 2042563-95-9

TP455( TP-455 | TP 455 )

Catalog No. M13178 CAS No. 2042563-95-9

TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TP455
  • Note
    Research use only, not for human use.
  • Brief Description
    TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.
  • Description
    TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells; TP455 proved to be more potent than morphine in writhing and tail immersion tests in mice with ED50 of 0.0328 mg/kg, exhibits great analgesic activity with an ED50 of 0.134 ± 0.011 mg/kg and minimum effective dose of 0.01 mg/kg; antagonizes CGS 21680-induced cell proliferation in cancer cell lines, inhibits GS 21680-dependent pERK1/2, pJNK MAPK kinase, and pAKT activation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TP-455 | TP 455
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2042563-95-9
  • Formula Weight
    353.4
  • Molecular Formula
    C17H15N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COC1=CC=CC=C1CNC2=NC(=C3C(=N2)SC(=N3)C4=CC=CO4)N
  • Chemical Name
    2-(2-furanyl)-N5-(2-methoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-5,7-diammine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gessi S, et al. Front Pharmacol. 2017 Dec 1;8:888. doi: 10.3389/fphar.2017.00888. 2. Varano F, et al. J Med Chem. 2016 Dec 8;59(23):10564-10576.
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