TP455( TP-455 | TP 455 )

Catalog No. M13178 CAS No. 2042563-95-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TP455
Note

Research use only, not for human use.
Brief Description

TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.
Description

TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells; TP455 proved to be more potent than morphine in writhing and tail immersion tests in mice with ED50 of 0.0328 mg/kg, exhibits great analgesic activity with an ED50 of 0.134 ± 0.011 mg/kg and minimum effective dose of 0.01 mg/kg; antagonizes CGS 21680-induced cell proliferation in cancer cell lines, inhibits GS 21680-dependent pERK1/2, pJNK MAPK kinase, and pAKT activation.
In Vitro

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In Vivo

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Synonyms

TP-455 | TP 455
Pathway

Apoptosis
Target

Adenosine Receptor
Recptor

Adenosine Receptor
Research Area

——
Indication

——

CAS Number

2042563-95-9
Formula Weight

353.4
Molecular Formula

C17H15N5O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

COC1=CC=CC=C1CNC2=NC(=C3C(=N2)SC(=N3)C4=CC=CO4)N
Chemical Name

2-(2-furanyl)-N5-(2-methoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-5,7-diammine

1. Gessi S, et al. Front Pharmacol. 2017 Dec 1;8:888. doi: 10.3389/fphar.2017.00888. 2. Varano F, et al. J Med Chem. 2016 Dec 8;59(23):10564-10576.

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