
TP455
CAS No. 2042563-95-9
TP455( TP-455 | TP 455 )
Catalog No. M13178 CAS No. 2042563-95-9
TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameTP455
-
NoteResearch use only, not for human use.
-
Brief DescriptionTP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.
-
DescriptionTP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells; TP455 proved to be more potent than morphine in writhing and tail immersion tests in mice with ED50 of 0.0328 mg/kg, exhibits great analgesic activity with an ED50 of 0.134 ± 0.011 mg/kg and minimum effective dose of 0.01 mg/kg; antagonizes CGS 21680-induced cell proliferation in cancer cell lines, inhibits GS 21680-dependent pERK1/2, pJNK MAPK kinase, and pAKT activation.
-
In Vitro——
-
In Vivo——
-
SynonymsTP-455 | TP 455
-
PathwayApoptosis
-
TargetAdenosine Receptor
-
RecptorAdenosine Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2042563-95-9
-
Formula Weight353.4
-
Molecular FormulaC17H15N5O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCOC1=CC=CC=C1CNC2=NC(=C3C(=N2)SC(=N3)C4=CC=CO4)N
-
Chemical Name2-(2-furanyl)-N5-(2-methoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-5,7-diammine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gessi S, et al. Front Pharmacol. 2017 Dec 1;8:888. doi: 10.3389/fphar.2017.00888.
2. Varano F, et al. J Med Chem. 2016 Dec 8;59(23):10564-10576.
molnova catalog



related products
-
Penbutolol sulfate
Penbutolol sulfate is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.
-
Labetalol
Labetalol is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situations. The pharmacokinetics of labetalol is affected by the common CYP2C19 polymorphisms.
-
Prazosin
Prazosin, an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.