TAS120( Futibatinib | FGFR-IN-1 )

Catalog No. M19782 CAS No. 1448169-71-8

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HPLC

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Product Name

TAS120
Note

Research use only, not for human use.
Brief Description

TAS-120 is a novel potent and highly selective FGFR inhibitor used for antitumor treatment.
Description

TAS-120 is a novel potent and highly selective FGFR inhibitor used for antitumor treatment.(In Vitro):Futibatinib (TAS-120) covalently binds to a highly conserved P-loop cysteine residue in the ATP pocket of FGFR.(In Vivo):Futibatinib (TAS-120) (3, 30, 100 mg/kg/day, p.o.) exerts an anti-tumor effect in mice. Futibatinib (TAS-120) shows anti-tumor effect by administering at moderate intervals, such as intermittent administration of every other day dosing and 2 times/week, and reducing the sustained elevation and weight suppression blood phosphorus level, and take a antitumor effective as daily administration.
In Vitro

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In Vivo

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Synonyms

Futibatinib | FGFR-IN-1
Pathway

Angiogenesis
Target

FGFR
Recptor

FGFR
Research Area

Cancer
Indication

Solid tumours

CAS Number

1448169-71-8
Formula Weight

418.45
Molecular Formula

C22H22N6O3
Purity

>98% (HPLC)
Solubility

DMSO:≥ 29 mg/mL (69.30 mM)
SMILES

COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Chemical Name

1-[(3S)-3-[4-amino-3-[2-(35-dimethoxyphenyl)ethynyl]-1H-pyrazolo[34-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one

1.Hiroaki OCHIIWA et al. Antitumor drug for intermittent administration of fgfr inhibitor. WO 2015008839 A1.

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