Pentoxifylline

Research use only, not for human use.

A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology.

A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production. (In Vitro):Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.Pentoxifylline results in high LC3-II/LC3-ratio.(In Vivo):Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment.

Pentoxifylline (0.1-50 mM; 24-48 hours) inhibits cell proliferation in a dose-dependent manner.Pentoxifylline (0.5 mM; 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells. Pentoxifylline (0.5 mM; 12-36 hours) induces autophagy in MDA-MB-231 cells.Pentoxifylline (0.5 mM; 24-48 hours) blocks cell cycle at the G0/G1 phase.Pentoxifylline results in high LC3-II/LC3-ratio. Cell Proliferation Assay Cell Line:MDA-MB-231 cells Concentration:0.1 mM, 1 mM, 5 mM , 10 mM, 50 mM Incubation Time:24 hours, 48 hoursResult:Inhibited cell proliferation in a dose-dependent manner.Apoptosis Analysis Cell Line:MDA-MB-231 cells Concentration:0.5 mM Incubation Time:12 hours, 24 hours, 36 hours Result:Induced apoptosis.Cell Autophagy AssayCell Line:MDA-MB-231 cellsConcentration:0.5 mM Incubation Time:24 hours, 48 hours Result:Induced approximately 20-28% of cell autophagy.Cell Cycle Analysis Cell Line:MDA-MB-231 cells Concentration:0.5 mM Incubation Time:24 hours, 48 hours Result:Induced G0/G1 phase arrest.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:0.5 mM Incubation Time:24 hours, 48 hours Result:Induced high LC3-II/LC3-ratio.

Pentoxifylline (200 mg/kg; i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment. Animal Model:Adult male Wistar rats 12-13-weeks-old (250-300 g)Dosage:200 mg/kg Administration:Intraperitoneal injection, at 1hr before and 3 hr after ischemia Result:Significantly improved the spatial memory and effects were significant different from those of sham-operated and vehicle groups.

NSC 637086 | Oxpentifylline

Apoptosis

Adenosine Receptor

A2| PDE

Cardiovascular Disease

——

6493-05-6

278.31

C13H18N4O3

>98% (HPLC)

soluble in Water

c12c(n(c(=O)n(c1=O)CCCCC(C)=O)C)ncn2C

1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion

(-20℃)

With Ice Pack

≥ 2 years