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POMHEX

CAS No. 2004714-34-3

POMHEX( —— )

Catalog No. M34848 CAS No. 2004714-34-3

Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    POMHEX
  • Note
    Research use only, not for human use.
  • Brief Description
    Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.
  • Description
    POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor.
  • In Vitro
    Cell Proliferation Assay Cell Line:ENO1-deleted (D423, red), ENO1-isogenically rescued (D423 ENO1, blue) and ENO1-WT (LN319, grey) cells.Concentration:78 nM.Incubation Time:8 h.Result:Down-regulated cell density.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    Glucokinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2004714-34-3
  • Formula Weight
    423.4
  • Molecular Formula
    C17H30NO9P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (236.18 mM; Ultrasonic )
  • SMILES
    O=C(OCOP(=O)(OCOC(=O)C(C)(C)C)C1C(=O)N(O)CCC1)C(C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yu-Hsi Lin, et al. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2020 Nov 23.?
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