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PF‐04447943
CAS No. 1082744-20-4
PF‐04447943 ( PF 04447943;PF04447943;PF-4447943 )
Catalog No. M10326 CAS No. 1082744-20-4
A potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 75 | Get Quote |
|
| 10MG | 120 | Get Quote |
|
| 25MG | 255 | Get Quote |
|
| 50MG | 408 | Get Quote |
|
| 100MG | 655 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePF‐04447943
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
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DescriptionA potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM; displays high selectivity versus PDEs1-8 and 10-11 (>150-fold over PDE1C, IC50=1394 nM); significantly increases neurite outgrowth and synapse formation in cultured hippocampal neurons at 30-100 nM; enhances synaptic plasticity and cognitive function in rodents.Alzheimer's Disease Phase 2 Clinical
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SynonymsPF 04447943;PF04447943;PF-4447943
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number1082744-20-4
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Formula Weight395.47
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Molecular FormulaC20H25N7O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 54.6 mg/mL 138.07 mM
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SMILESCC1CN(CC1C2=NC3=C(C=NN3C4CCOCC4)C(=O)N2)CC5=NC=CC=N5
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Chemical Name6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hutson PH, et al. Neuropharmacology. 2011 Sep;61(4):665-76.
2. Verhoest PR, et al. J Med Chem. 2012 Nov 8;55(21):9045-54.
3. Schwam EM, et al. Curr Alzheimer Res. 2014;11(5):413-21.
2. Verhoest PR, et al. J Med Chem. 2012 Nov 8;55(21):9045-54.
3. Schwam EM, et al. Curr Alzheimer Res. 2014;11(5):413-21.
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