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PF‐04447943

CAS No. 1082744-20-4

PF‐04447943 ( PF 04447943;PF04447943;PF-4447943 )

Catalog No. M10326 CAS No. 1082744-20-4

A potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF‐04447943
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
  • Description
    A potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM; displays high selectivity versus PDEs1-8 and 10-11 (>150-fold over PDE1C, IC50=1394 nM); significantly increases neurite outgrowth and synapse formation in cultured hippocampal neurons at 30-100 nM; enhances synaptic plasticity and cognitive function in rodents.Alzheimer's Disease Phase 2 Clinical
  • Synonyms
    PF 04447943;PF04447943;PF-4447943
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    1082744-20-4
  • Formula Weight
    395.47
  • Molecular Formula
    C20H25N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 54.6 mg/mL 138.07 mM
  • SMILES
    CC1CN(CC1C2=NC3=C(C=NN3C4CCOCC4)C(=O)N2)CC5=NC=CC=N5
  • Chemical Name
    6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hutson PH, et al. Neuropharmacology. 2011 Sep;61(4):665-76.
2. Verhoest PR, et al. J Med Chem. 2012 Nov 8;55(21):9045-54.
3. Schwam EM, et al. Curr Alzheimer Res. 2014;11(5):413-21.
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