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PBRM1-BD2-IN-2
CAS No. 2819989-57-4
PBRM1-BD2-IN-2( —— )
Catalog No. M35349 CAS No. 2819989-57-4
PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 178 | Get Quote |
|
| 5MG | 255 | Get Quote |
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| 10MG | 375 | Get Quote |
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| 25MG | 545 | Get Quote |
|
| 50MG | 762 | Get Quote |
|
| 100MG | 1017 | Get Quote |
|
| 500MG | 2043 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePBRM1-BD2-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionPBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively.
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DescriptionPBRM1-BD2-IN-2 is a selective and cell-activepolybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer.
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In VitroPBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line.PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively.PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM.Cell Viability Assay Cell Line:Human prostate cell lines LNCaP, PC3, and RWPE-1Concentration:0, 0.1, 1, and 10 μM Incubation Time:5 days Result:Inhibited LNCaP growth at higher concentrations.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorEpigenetic Reader Domain
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Research Area——
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Indication——
Chemical Information
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CAS Number2819989-57-4
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Formula Weight311.14
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Molecular FormulaC14H9Cl2FN2O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C=2C(NC(N1)C3=C(Cl)C=CC=C3F)=CC=CC2Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shifali Shishodia, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.?
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