PBRM1-BD2-IN-2

Research use only, not for human use.

PBRM1-BD2-IN-2, a selective and cell-active inhibitor of the polybromo-1 (PBRM1) bromodomain, exhibits binding affinity and inhibitory activity specifically targeting the PBRM1-BD2 domain, with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively.

PBRM1-BD2-IN-2 is a selective and cell-activepolybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer.

PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line.PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively.PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM.Cell Viability Assay Cell Line:Human prostate cell lines LNCaP, PC3, and RWPE-1Concentration:0, 0.1, 1, and 10 μM Incubation Time:5 days Result:Inhibited LNCaP growth at higher concentrations.

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Chromatin/Epigenetic

Epigenetic Reader Domain

Epigenetic Reader Domain

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2819989-57-4

311.14

C14H9Cl2FN2O

>98% (HPLC)

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O=C1C=2C(NC(N1)C3=C(Cl)C=CC=C3F)=CC=CC2Cl

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(-20℃)

With Ice Pack

≥ 2 years