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Home - Products - Metabolic Enzyme/Protease - Factor Xa - Otamixaban

Otamixaban

CAS No. 193153-04-7

Otamixaban( FXV-673 )

Catalog No. M13026 CAS No. 193153-04-7

A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Otamixaban
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM.
  • Description
    A potent and selective factor Xa (FXa) inhibitor with Ki of 0.4 nM; shows >1,000-fold selectivity over thrombin, activated protein C (aPC), plasmin, and tissue-plasminogen activator (t-PA); dose-dependently prolongs the time to vessel occlusion and inhibits thrombus formation in canine models of thrombosis.Thrombosis Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    FXV-673
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Factor Xa
  • Recptor
    Factor Xa
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    193153-04-7
  • Formula Weight
    446.4984
  • Molecular Formula
    C25H26N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C[C@@H](NC(C1=CC=C(C2=CC=[N+]([O-])C=C2)C=C1)=O)[C@@H](CC3=CC=CC(C(N)=N)=C3)C(OC)=O
  • Chemical Name
    Benzenepropanoic acid, 3-(aminoiminomethyl)-.alpha.-[(1R)-1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]-, methyl ester, (.alpha.R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Guertin KR, et al. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1671-4. 2. Chu V, et al. Thromb Res. 2001 Aug 15;103(4):309-24. 3. Rebello SS, et al. J Cardiovasc Pharmacol. 2001 Aug;38(2):288-97.
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