ODM-201 ( BAY-1841788;Darolutamide )

Catalog No. M11201 CAS No. 1297538-32-9

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Product Name

ODM-201
Note

Research use only, not for human use.
Brief Description

A potent wt/mutant androgen receptor (AR) inhibitor with Ki of 11 nM.
Description

A potent wt/mutant androgen receptor (AR) inhibitor with Ki of 11 nM; inhibits wtAR/AR(F876L) with IC50 of 65/66 nM respectively, weak inhibition on AR(W741L) and AR(T877A); inhibits the nuclear translocation of AR and more efficaciously than enzalutamide or ARN-509 in VCaP cell line proliferation assay; reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model.Prostate Cancer Phase 3 Clinical
Synonyms

BAY-1841788;Darolutamide
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

AndrogenReceptor
Research Area

Cancer
Indication

Prostate Cancer

CAS Number

1297538-32-9
Formula Weight

398.85
Molecular Formula

C19H19ClN6O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 44 mg/mL
SMILES

O=C(C1=NNC(C(O)C)=C1)N[C@@H](C)CN2N=C(C3=CC=C(C#N)C(Cl)=C3)C=C2
Chemical Name

1H-Pyrazole-3-carboxamide, N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-

1. Moilanen AM, et al. Sci Rep. 2015 Jul 3;5:12007.
2. Fizazi K, et al. Lancet Oncol. 2014 Aug;15(9):975-85.
3. Cancer Discov. 2014 Sep;4(9):OF10.

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