Nitroxoline( Nitroxoline, 5-nitrox, 5-NOK, Cysto-saar plus, Nibiol )

Catalog No. M14371 CAS No. 4008-48-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Nitroxoline
Note

Research use only, not for human use.
Brief Description

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.
Description

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
In Vitro

Cell Viability Assay Cell Line:H446, H1882, H1417, and H1688 cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM Incubation Time:24 hours Result:Effectively inhibit cell survival of small-cell lung cancer (SCLC) cells.Western Blot Analysis Cell Line:H446, H1882, H1417 cells Concentration:5 μM, 10 μM, 20 μM Incubation Time:24 hours Result:Suppressed antiapoptotic proteins (such as Bcl-2 and MCL1) and upregulated proapoptotic protein Bim.
In Vivo

Animal Model:C3H/He mice bladder injected with MBT-2 cells Dosage:15 mg/kg or 60mg/kg Administration:Orally gavage; five times a week on days 1, 2, 4, 5, 7, 8, 10, and 11.Result:Resulted in significant inhibition of tumor growth.
Synonyms

Nitroxoline, 5-nitrox, 5-NOK, Cysto-saar plus, Nibiol
Pathway

Others
Target

Other Targets
Recptor

Fe2+/Zn2+ ions
Research Area

Infection
Indication

——

1.Chang WL, et al. Oncotarget. 2015 Nov 24;6(37):39806-20.

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