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Naltrexone
CAS No. 16590-41-3
Naltrexone( —— )
Catalog No. M12531 CAS No. 16590-41-3
A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNaltrexone
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
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DescriptionA potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).Alcoholism Approved.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research AreaNeurological Disease
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IndicationAlcoholism
Chemical Information
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CAS Number16590-41-3
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Formula Weight341.4009
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Molecular FormulaC20H23NO4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESC1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O
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Chemical NameMorphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5α)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70.
2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809.
3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.
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