NS309

Research use only, not for human use.

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels).

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

NS309; NS-309; NS 309

Immunology/Inflammation

ROS

Potassium Channel

Cardiovascular Disease

——

18711-16-5

231.04

C8H4Cl2N2O2

96%

DMSO : ≥ 50 mg/mL; 216.41 mM

Clc2ccc1c(NC(=O)C1=NO)c2Cl

(Z)-6,7-dichloro-3-(hydroxyimino)indolin-2-one

(-20℃)

With Ice Pack

≥ 2 years