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Zotizalkib
CAS No. 2648641-36-3
Zotizalkib( —— )
Catalog No. M37625 CAS No. 2648641-36-3
Zotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 334 | In Stock |
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| 5MG | 303 | In Stock |
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| 10MG | 487 | In Stock |
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| 25MG | 938 | In Stock |
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| 50MG | 1442 | In Stock |
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| 100MG | 2027 | In Stock |
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| 200MG | 2744 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZotizalkib
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NoteResearch use only, not for human use.
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Brief DescriptionZotizalkib (TPX-0131) is an orally active and selective ALK inhibitor with antitumor activity for the study of non-small cell lung cancer.
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DescriptionZotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC50 of 0.3 nM), L1196M (IC50 of 0.3 nM). Zotizalkib has strong antitumor activities.
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In Vitro——
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In VivoAnimal Model:Female SCID/beige mice (5-8 weeks old) bearing Ba/F3 cells Dosage:2 mg/kg, 5 mg/kg, and 10 mg/kg Administration:p.o.; twice a day; for 2 weeks Result:Caused complete tumor regression in ALK mutation-dependent xenograft models.
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Synonyms——
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PathwayAngiogenesis
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TargetALK
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RecptorALK
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Research Area——
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Indication——
Chemical Information
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CAS Number2648641-36-3
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Formula Weight447.41
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Molecular FormulaC21H20F3N5O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (139.69 mM; Ultrasonic (<80°C)
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SMILESC(F)(F)[C@H]1N2C=3C(=CN4C(N3)=C(C=N4)C(=O)NC(C)(C)COC=5C(C2)=CC(F)=CC5)OC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brion W Murray, et al. TPX-0131, a Potent CNS-Penetrant, Next-Generation Inhibitor of Wild-Type ALK and ALK-Resistant Mutations. Mol Cancer Ther. 2021 Jun 22;molcanther.0221.2021.?
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