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6-Azido-hexylamine
CAS No. 349553-73-7
6-Azido-hexylamine( —— )
Catalog No. M35207 CAS No. 349553-73-7
6-Azido-hexylamine is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 29 | In Stock |
|
| 100MG | 45 | In Stock |
|
| 200MG | 76 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product Name6-Azido-hexylamine
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NoteResearch use only, not for human use.
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Brief Description6-Azido-hexylamine is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs).
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Description6-Azido-hexylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 6-Azido-hexylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In Vivo——
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Synonyms——
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PathwayAntibody Drug Conjugates (ADC)
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TargetADCs Linker/Click Chemistry
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RecptorADC Linker
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Research Area——
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Indication——
Chemical Information
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CAS Number349553-73-7
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Formula Weight142.2022
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Molecular FormulaC6H14N4
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Purity>98% (HPLC)
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Solubility——
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SMILESNCCCCCCN=[N+]=[N-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.?
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SPDB
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6-Maleimidohexanoic ...
A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity; a useful protective group in antibody drug conjugates.
