Ganoderic acid DM

Research use only, not for human use.

Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1).

Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.

Ganoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells.Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA.Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity.Cell Viability Assay Cell Line:MCF-7 and MDA-MB-231 cells.Concentration:0-100 μM.Incubation Time:48 h.Result:Decreased the cell viability in breast cancer cells.Cell Viability Assay Cell Line:RAW-D cells.Concentration:0-100 μg/mL.Incubation Time:0-100 μg/mL.Result:Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.

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Others

Other Targets

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173075-45-1

468.7

C30H44O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (106.68 mM)

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(-20℃)

With Ice Pack

≥ 2 years