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Cortagine

CAS No. ——

Cortagine( —— )

Catalog No. M30731 CAS No. ——

Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces defensive behavior in vivo.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Cortagine
  • Note
    Research use only, not for human use.
  • Brief Description
    Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces defensive behavior in vivo.
  • Description
    Potent and selective corticotrophin releasing factor receptor 1 (CRF1) agonist (EC50 = 0.18 nM for rat CRF1). Displays anxiolytic and antidepressant activity in vivo. Microinfusion into mouse prefrontal cortex reduces defensive behavior in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    4442.06
  • Molecular Formula
    C192H323N55O63S
  • Purity
    >98% (HPLC)
  • Solubility
    0.01M PBS:1 mg/mL
  • SMILES
    [H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(N)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tezval et al (2004) Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model. Proc.Natl.Acad.Sci.U.S.A. 101 9468 PMID:
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