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NS13001

CAS No. 1063331-94-1

NS13001( N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine | N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine )

Catalog No. M23269 CAS No. 1063331-94-1

NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
2MG 43 In Stock
5MG 93 In Stock
10MG 170 In Stock
25MG 306 In Stock
50MG 423 In Stock
100MG 609 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NS13001
  • Note
    Research use only, not for human use.
  • Brief Description
    NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).
  • Description
    NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine | N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SK2|SK3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1063331-94-1
  • Formula Weight
    353.81
  • Molecular Formula
    C17H16ClN7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 90 mg/mL (254.37 mM; Need ultrasonic)
  • SMILES
    Cc1cc(C)nn1-c(nc1Nc(cc2)ccc2Cl)nc2c1ncn2C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.
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