Cart
sales@molnova.com
ABT-724
CAS No. 70006-24-5
ABT-724( —— )
Catalog No. M21091 CAS No. 70006-24-5
ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 87 | In Stock |
|
| 5MG | 78 | In Stock |
|
| 25MG | 171 | In Stock |
|
| 50MG | 251 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameABT-724
-
NoteResearch use only, not for human use.
-
Brief DescriptionABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
-
DescriptionABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM).
-
In VitroABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations.
-
In VivoABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats. Animal Model:Male adult Wistar rats (~300 g) Dosage:8.8 μg/kg Administration:Subcutaneous injection; daily; for 5 daysResult:Dose-dependently facilitated penile erection.
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetDopamine Receptor
-
RecptorD4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number70006-24-5
-
Formula Weight293.37
-
Molecular FormulaC17H19N5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESc1ccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)nc1
-
Chemical Name1H-Benzimidazole 2-((4-(2-pyridinyl)-1-piperazinyl)methyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Brioni J D Moreland R B Cowart M et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats[J]. Proceedings of the National Academy of Sciences 2004 101(17):6758-6763.
molnova catalog
related products
-
BP-897
BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM.
-
Veralipride
Veralipride is an antagonist of D2 receptor.
-
MLS1547
MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
