FLI-06( FLI06 | FLI 06 | FLI06 )

Catalog No. M17475 CAS No. 313967-18-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

FLI-06
Note

Research use only, not for human use.
Brief Description

FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
Description

FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which was accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 is the first small molecule acting at such an early stage in secretory traffic. Notch signaling has a pivotal role in numerous cell-fate decisions, and its aberrant activity leads to developmental disorders and cancer.
In Vitro

FLI-06, disrupted the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibited general secretion at a step before exit from the endoplasmic reticulum. In FLI-06–treated cells, no APPCTF accumulates despite strongly reduced Aβ secretion, suggesting that it acts upstream of α-secretase and β-secretase cleavage. FLI-06 is a very useful chemical probe to study the inhibition of membrane traffic at pre- ER-exit site (ERES) stages without fusion of ER-Golgi.
In Vivo

——
Synonyms

FLI06 | FLI 06 | FLI06
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

Notch
Research Area

Cancer
Indication

——

CAS Number

313967-18-9
Formula Weight

438.52
Molecular Formula

C25H30N2O5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 38 mg/mL; 86.66 mM
SMILES

CC1=C(C(c2ccc(cc2)[N+](=O)[O-])C2=C(CC(C)(C)CC2=O)N1)C(=O)OC1CCCCC1
Chemical Name

cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

1. Kr?mer A, et al. Nat Chem Biol. 2013, 9(11), 731-738.

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