SPOP-IN-6b( SPOP IN-6b | SPOP IN 6b | SPOP-IN-6b )

Catalog No. M13403 CAS No. 2136270-20-5

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HNMR

HPLC

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Product Name

SPOP-IN-6b
Note

Research use only, not for human use.
Brief Description

SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor.
Description

SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP); suppresses oncogenic SPOP-signaling pathways, and kills human ccRCC cells that are dependent on oncogenic cytoplasmic SPOP.
In Vitro

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In Vivo

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Synonyms

SPOP IN-6b | SPOP IN 6b | SPOP-IN-6b
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

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Indication

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CAS Number

2136270-20-5
Formula Weight

500.603
Molecular Formula

C28H32N6O3
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(C(C(N1CCC2=CC=CC=C2)=N)=CC3=C1N=C(C(C)=CC=C4)N4C3=O)NCCCN5CCOCC5
Chemical Name

2-imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide

1. Guo ZQ, et al. Cancer Cell. 2016 Sep 12;30(3):474-484.

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