2-Deoxy-D-glucose

Research use only, not for human use.

2-Deoxy-D-glucose, an analog of glucose, is a glycolytic inhibitor with antiviral activity.

2-Deoxy-D-glucose, an analog of glucose, is a glycolytic inhibitor with antiviral activity.(In Vitro):2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells.(In Vivo):2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle.

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Ba 2758 | NSC 15193

Others

Other Targets

glycolysis

Cancer

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154-17-6

164.16

C6H12O5

>98% (HPLC)

Ethanol: 1 mg/mL (6.09 mM) DMSO: 32 mg/mL (194.93 mM) Water: 32 mg/mL (194.93 mM)

O=CC[C@H]([C@@H]([C@@H](CO)O)O)O

2-Deoxy-D-arabinohexose

(-20℃)

With Ice Pack

≥ 2 years