Saquinavir

Research use only, not for human use.

Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.

Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays; binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus; inhibits both HIV-1 and HIV-2 proteases; used to treat or prevent HIV/AIDS.HIV Infection Approved(In Vitro):Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.

Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. HIV protease is vital for both viral replication within the cell and release of mature viral particles from an infected cell. Saquinavir binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus. Saquinavir inhibits both HIV-1 and HIV-2 proteases.Studies have also looked at Saquinavir as a possible anti-cancer agent.

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Ro 31-8959

Microbiology/Virology

HIV

HIV

Infection

HIV Infection

127779-20-8

670.8408

C38H50N6O5

>98% (HPLC)

10 mM in DMSO

CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(C(CC3=CC=CC=C3)NC(=O)C(CC(=O)N)NC(=O)C4=NC5=CC=CC=C5C=C4)O

Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-

(-20℃)

With Ice Pack

≥ 2 years