Letaxaban

Research use only, not for human use.

Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa.

Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA; In human plasma, TAK-442 doubles FXa-induced clotting time, prothrombin time (PT), and activated partial thromboplastin time at 0.19, 0.55, and 0.59 uM, respectively; demonstrates antithrombotic effects in rabbit model of venous thrombosis.Thrombosis Phase 2 Discontinued.

——

——

TAK-442 | TAK442

Metabolic Enzyme/Protease

Factor Xa

Factor Xa

Cardiovascular Disease

Thrombosis

870262-90-1

479.98

C22H26ClN3O5S

>98% (HPLC)

——

O=C1NCCCN1C2CCN(C([C@H](O)CS(=O)(C3=CC=C4C=C(Cl)C=CC4=C3)=O)=O)CC2

(S)-1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one

(-20℃)

With Ice Pack

≥ 2 years