Cart
sales@molnova.com
LY-2940094
CAS No. 1307245-86-8
LY-2940094( —— )
Catalog No. M23461 CAS No. 1307245-86-8
LY-2940094 decreases ethanol self-administration in animal models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 97 | In Stock |
|
| 5MG | 149 | In Stock |
|
| 10MG | 259 | In Stock |
|
| 25MG | 514 | In Stock |
|
| 50MG | 737 | In Stock |
|
| 100MG | 1017 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLY-2940094
-
NoteResearch use only, not for human use.
-
Brief DescriptionLY-2940094 decreases ethanol self-administration in animal models.
-
DescriptionLY-2940094 decreases ethanol self-administration in animal models. LY-2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).
-
In Vitro——
-
In VivoAnimal Model:Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)Dosage:3, 10, or 30 mg/kg; 2-3 mL/kg Administration:Administered orally; daily; 4 days Result:Reduced homecage ethanol self-administration.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetOpioid Receptor
-
RecptorNOP receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1307245-86-8
-
Formula Weight480.96
-
Molecular FormulaC22H23ClF2N4O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO:41.67 mg/mL (86.64 mM; Need ultrasonic)
-
SMILESCc(c(CN(CC1)CCC1(c(s1)c2cc1Cl)OCC2(F)F)c1)nn1-c1ncccc1CO
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.
molnova catalog
related products
-
PF-CBP1 hydrochlorid...
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
-
PF-04455242
PF-04455242 is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively.
-
NKTR-181
A novel, long-acting and orally active, selective mu-opioid agonist.
