LGD-2226 ( LGD2226 )

Catalog No. M14078 CAS No. 328947-93-9

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Datasheet

HNMR

HPLC

MSDS

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Product Name

LGD-2226
Note

Research use only, not for human use.
Brief Description

LGD-2226 (LGD2226) is an orally active, selective androgen receptor modulator (SARM) with binding Ki of 1 nM.
Description

LGD-2226 (LGD2226) is an orally active, selective androgen receptor modulator (SARM) with binding Ki of 1 nM, >1000-fold selectivity over GR,PR, MR and ER; LGD2226 is fully active in cell-based models of bone and muscle, exhibits anabolic activity on muscle and bone with reduced impact on prostate growth in rodent models; LGD2226 is also efficacious in a sex-behavior model in male rats measuring mounts, intromissions, ejaculations, and copulation efficiency.Osteoporosis Discontinued
Synonyms

LGD2226
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor (AR)
Research Area

Metabolic Disease
Indication

Osteoporosis

CAS Number

328947-93-9
Formula Weight

392.23
Molecular Formula

C14H9F9N2O
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1NC2=C(C=C(N(CC(F)(F)F)CC(F)(F)F)C=C2)C(C(F)(F)F)=C1
Chemical Name

6-(bis-(2,2,2-trifluoroethyl)amino)-4-trifluoromethyl-1H-quinolin-2-one

1. Miner JN, et al. Endocrinology. 2007 Jan;148(1):363-73.
2. van Oeveren A, et al. J Med Chem. 2006 Oct 19;49(21):6143-6.

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