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Gly-Arg-Gly-Asp-Ser

CAS No. 96426-21-0

Gly-Arg-Gly-Asp-Ser( —— )

Catalog No. M30158 CAS No. 96426-21-0

Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gly-Arg-Gly-Asp-Ser
  • Note
    Research use only, not for human use.
  • Brief Description
    Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.
  • Description
    Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.(In Vitro):Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM. Gly-Arg-Gly-Asp-Ser-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation.
  • In Vitro
    Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM. Gly-Arg-Gly-Asp-Ser-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    IC50: 5 μM (αvβ3), 6.5 μM (αvβ5)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    96426-21-0
  • Formula Weight
    490.47
  • Molecular Formula
    C17H30N8O9
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL (203.89 mM; Need ultrasonic);H2O : 33.33 mg/mL (67.96 mM; Need ultrasonic)
  • SMILES
    ——
  • Chemical Name
    Sequence:Gly-Arg-Gly-Asp-Ser

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.
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