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Home - Products - GPCR/G Protein - Antibacterial - GSK-729

GSK-729

CAS No. 1260243-45-5

GSK-729( GSK 729 | GSK729 )

Catalog No. M11073 CAS No. 1260243-45-5

A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK-729
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM.
  • Description
    A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3; selectively pulls down EchA6 in a stereospecific manner in M. bovis BCG extracts, competes with CoA-binding, suppresses mycolic acid synthesis, and are bactericidal in mouse model of chronic tuberculosis infection.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK 729 | GSK729
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1260243-45-5
  • Formula Weight
    339.318
  • Molecular Formula
    C16H16F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=C2N[C@H](C3=CC=C(CC)C=C3)C[C@H](C(F)(F)F)N2N=C1)O
  • Chemical Name
    (5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.
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