GSK-729 ( GSK 729;GSK729 )

Catalog No. M11073 CAS No. 1260243-45-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

GSK-729
Note

Research use only, not for human use.
Brief Description

A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM.
Description

A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3; selectively pulls down EchA6 in a stereospecific manner in M. bovis BCG extracts, competes with CoA-binding, suppresses mycolic acid synthesis, and are bactericidal in mouse model of chronic tuberculosis infection.
Synonyms

GSK 729;GSK729
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

1260243-45-5
Formula Weight

339.32
Molecular Formula

C16H16F3N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C2N[C@H](C3=CC=C(CC)C=C3)C[C@H](C(F)(F)F)N2N=C1)O
Chemical Name

(5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.

Calculator

molnova catalog