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Eribaxaban
CAS No. 536748-46-6
Eribaxaban( PD-0348292 | PD0348292 | PD 0348292 )
Catalog No. M14904 CAS No. 536748-46-6
A potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameEribaxaban
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM.
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DescriptionA potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM; displays >1,000-fold selectivity over a series of related serine proteases (thrombin, activated protein C, plasmin, tissue plasminogen activator and trypsin); potently inhibits thrombosis and shows potential for s for the treatment and prevention of thrombotic disorders.Thrombosis Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPD-0348292 | PD0348292 | PD 0348292
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PathwayMetabolic Enzyme/Protease
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TargetFactor Xa
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RecptorFactor Xa
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number536748-46-6
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Formula Weight484.912
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Molecular FormulaC24H22ClFN4O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(Cl)C=C1)N2C[C@@H](C[C@H]2C(NC3=CC=C(N4C=CC=CC4=O)C=C3F)=O)OC
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Chemical Name(2R,4R)-1-N-(4-chlorophenyl)-2-N-[2-fluoro-4-(2-oxopyridin-1-yl)phenyl]-4-methoxypyrrolidine-1,2-dicarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kohrt JT, et al. Chem Biol Drug Des. 2007 Aug;70(2):100-12.
2. McBane RD 2nd, et al. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):413-8.
3. Karnicki K, et al. Thromb Haemost. 2008 Apr;99(4):759-66.
4. Cohen AT, et al. J Thromb Haemost. 2013 Aug;11(8):1503-10.
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