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Eluxadoline

CAS No. 864821-90-9

Eluxadoline( JNJ 27018966 | JNJ27018966 )

Catalog No. M16275 CAS No. 864821-90-9

A potent, selective, orally bioavailable μ-opioid receptor agonist and a δ-opioid receptor antagonist for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Eluxadoline
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally bioavailable μ-opioid receptor agonist and a δ-opioid receptor antagonist for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D).
  • Description
    A potent, selective, orally bioavailable μ-opioid receptor agonist and a δ-opioid receptor antagonist for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D).Irritable Bowel Syndrome Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNJ 27018966 | JNJ27018966
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    864821-90-9
  • Formula Weight
    569.651
  • Molecular Formula
    C32H35N5O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CC(=CC(=C1C[C@@H](C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)[C@@H](C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N
  • Chemical Name
    5-(((S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)-N-((S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl)propanamido)methyl)-2-methoxybenzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dove LS, et al. Gastroenterology. 2013 Aug;145(2):329-38.e1. 2. Fujita W, et al. Biochem Pharmacol. 2014 Dec 1;92(3):448-56. 3. Davenport JM, et al. J Clin Pharmacol. 2015 May;55(5):534-42.
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