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4-IPP

CAS No. 41270-96-6

4-IPP( 4-Iodo-6-phenylpyrimidine )

Catalog No. M21584 CAS No. 41270-96-6

4-IPP is an irreversible?inhibitor of macrophage migration inhibitory factor (MIF).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    4-IPP
  • Note
    Research use only, not for human use.
  • Brief Description
    4-IPP is an irreversible?inhibitor of macrophage migration inhibitory factor (MIF).
  • Description
    4-IPP is an irreversible?inhibitor of macrophage migration inhibitory factor (MIF).
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:BMMs Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM Incubation Time:24 hours, 72 hours Result:Inhibited osteoclastogenesis in a dose-dependent manner.Western Blot Analysis Cell Line:BMMs Concentration:5 μM,10 μM, 20 μM Incubation Time:1 day, 3 days, 5 days Result:Inhibited RANKL-induced osteoclast differentiation and bone resorption.
  • In Vivo
    Animal Model:8-weeks-old C57BL/6J male mice Dosage:1 mg/kg, 5 mg/kg Administration:Intraperitoneal injection; every 2 days; for 8 weeks Result:Alleviated OVX-induced osteoporosis.
  • Synonyms
    4-Iodo-6-phenylpyrimidine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    41270-96-6
  • Formula Weight
    282.08
  • Molecular Formula
    C10H7IN2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (354.51 mM)
  • SMILES
    Ic1cc(ncn1)-c1ccccc1
  • Chemical Name
    4-Iodo-6-phenyl-pyrimidine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zheng L et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33(6):7667-7683.
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